<Suppliers Price>

SKF-34288 hydrochloride

Names

[ CAS No. ]:
320386-54-7

[ Name ]:
SKF-34288 hydrochloride

[Synonym ]:
3-Mercapto-2-pyridinecarboxylic Acid Hydrochloride
3-Mercaptopicolinic Acid Hydrochloride

Biological Activity

[Description]:

SKF-34288 hydrochloride (3-Mercaptopicolinic acid) is a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor.SKF-34288 hydrochloride is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway[1]. SKF-34288 hydrochloride inhibits Asn metabolism and results in an increase in amino acids and amides[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

IC50: PEPCK[1]


[References]

[1]. https://www.ncbi.nlm.nih.gov/pubmed/26322521

[2]. Bailey KJ, et al. Nitrogen recycling from the xylem in rice leaves: dependence upon metabolism and associated changes in xylem hydraulics. J Exp Bot. 2016 Apr;67(9):2901-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C6H6ClNO2S

[ Molecular Weight ]:
191.63500

[ Exact Mass ]:
190.98100

[ PSA ]:
88.99000

[ LogP ]:
1.87050


Related Compounds