Haloxon

Names

[ CAS No. ]:
321-55-1

[ Name ]:
Haloxon

[Synonym ]:
2-Ethylhexyl 4,4-bis(3-butoxy-3-oxopropyl)-10-ethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate
di(2-butoxycarbonylethyl)tin S,S'-bis-(2-ethylhexyl thioglycolate)
Di-(2-chlorethyl)-3-chloro-4-methylcoumarin-7-yl-phosphat
8-Oxa-3,5-dithia-4-stannatetradecanoicacid,4,4-bis(3-butoxy-3-oxopropyl)-10-ethyl-7-oxo-,2-ethylhexyl ester
Haloxon

Biological Activity

[Description]:

Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5g/cm3

[ Boiling Point ]:
504.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₄Cl₃O₆P

[ Molecular Weight ]:
415.59000

[ Flash Point ]:
438.8ºC

[ Exact Mass ]:
413.95900

[ PSA ]:
84.78000

[ LogP ]:
4.75250

[ Index of Refraction ]:
1.561

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN5250000

CHEMICAL NAME :: Coumarin, 3-chloro-7-hydroxy-4-methyl-, bis(2-chloroethyl) phosphate

CAS REGISTRY NUMBER :: 321-55-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H14-Cl3-O6-P

MOLECULAR WEIGHT :: 415.60

WISWESSER LINE NOTATION :: T66 BOVJ DG E1 IOPO&O2GO2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 763 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 10 mg/L

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 10,143,1982 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
GN5250000

[ HS Code ]:
2932209090

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effects of selected organophosphate insecticides on serum cholinesterase isoenzyme patterns in the rat.

Vet. Hum. Toxicol. 38(3) , 196-9, (1996)

The serum cholinesterase (ChE) isoenzyme in rats shows 6 bands after polyacrylamide gradient gel electrophoresis. The effects of organophosphates (fenthion, chlorpyrifos, diazinon, bromophos, propapho...

Effect of some anthelmintics on malate dehydrogenase activity and mortality in two avian nematodes Ascaridia galli and Heterakis gallinae.

Angew. Parasitol. 27(3) , 175-80, (1986)

Cambendazole and tiabendazole at 10(-4) M concentrations caused mortality in both the parasites after 10 min and 20 min, respectively. H. gallinae was killed by 10(-4) M haloxon but A. galli remained ...

Effect of cambendazole and haloxon on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae (Nematoda).

Angew. Parasitol. 31(2) , 101-5, (1990)

Cambendazole 10(-4) M significantly reduced the level of glycogen in both the parasites. Lactic acid level was found enhanced. Oxygen consumption was suppressed by 63 and 94% in A. galli and H. gallin...