Acetyl coenzyme A lithium

Names

[ Name ]:
Acetyl coenzyme A lithium

[Synonym ]:
Acetyl-S-CoA Li3
acetyl-CoA
Acetyl coenzyme A lithium salt
Lithiumacetyl-CoA

Biological Activity

[Description]:

Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis[1][2][3][4].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Acetyl coenzyme A lithium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A lithium; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h)[2].

[In Vivo]

Acetyl coenzyme A lithium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy[2][3].Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A lithium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A lithium concentrations in the brain and actually increase hepatic Acetyl coenzyme A lithium and protein acetylation levels[4].

[References]

[1]. Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50.

[2]. Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25.

[3]. Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93.

[4]. Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₅Li₃N₇O₁₇P₃S

[ Molecular Weight ]:
827.37000

[ Exact Mass ]:
827.15000

[ PSA ]:
426.85000

[ LogP ]:
1.36220

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

Articles

Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans.

Proc. Natl. Acad. Sci. U. S. A. 98(4) , 2017-22, (2001)

Choline acetyltransferase (ChAT; EC ) catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Mutations in genes encoding ChAT affecting motility...

Congenital myasthenic syndrome with episodic apnea in patients homozygous for a CHAT missense mutation.

Arch. Neurol. 60(5) , 761-3, (2003)

The syndrome of congenital myasthenia with episodic apnea (CMS-EA) was previously found to be due to mutations in the choline acetyltransferase gene (CHAT).To identify the mutations underlying CMS-EA ...

Productive infection and bICP0 early promoter activity of bovine herpesvirus 1 are stimulated by E2F1.

J. Virol. 84(13) , 6308-17, (2010)

Bovine herpesvirus 1 (BoHV-1) is an important viral pathogen of cattle. Like other members of the subfamily Alphaherpesvirinae, BoHV-1 establishes latency in sensory neurons and has the potential to r...