Pilloin

Names

[ Name ]:
Pilloin

[Synonym ]:
3',5-Dihydroxy-4',7-dimethoxyflavone
7,4'-dimethoxy-3'-hydroxyflavone
5,3'-dihydroxy-7,4'-dimethoxyflavone
4H-1-Benzopyran-4-one, 5-hydroxy-2- (3-hydroxy-4-methoxyphenyl)-7-methoxy-
4H-1-Benzopyran-4-one, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-
luteolin 7,4'-dimethyl ether
5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-chromen-4-one
Pilloin

Biological Activity

[Description]:

Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Fotios Michelis, et al. Effects of the Flavonoid Pilloin Isolated from Marrubium cylleneum on Mitogen-Induced Lymphocyte Transformation. Journal Pharmaceutical Biology. 2002.

[2]. Yun-Chen Tsai, et al. Pilloin, A Flavonoid Isolated From Aquilaria sinensis, Exhibits Anti-Inflammatory Activity In Vitro and In Vivo. Molecules. 2018 Dec 2;23(12):3177.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
569.6±50.0 °C at 760 mmHg

[ Melting Point ]:
230-232℃ (Decomposition) (methanol )

[ Molecular Formula ]:
C₁₇H₁₄O₆

[ Molecular Weight ]:
314.289

[ Flash Point ]:
213.9±23.6 °C

[ Exact Mass ]:
314.079041

[ PSA ]:
89.13000

[ LogP ]:
3.35

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.646

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%