ZnAF-2

Names

[ Name ]:
ZnAF-2

[Synonym ]:
6-{2-[Bis(2-pyridylmethyl)amino]ethylamino}fluorescein

Biological Activity

[Description]:

ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2?-specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2?. Little affinity for Ca2?, Mg2?, Na? or K?.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
847.8ºC at 760 mmHg

[ Molecular Formula ]:
C₃₄H₂₈N₄O₅

[ Molecular Weight ]:
572.61000

[ Flash Point ]:
466.5ºC

[ Exact Mass ]:
572.20600

[ PSA ]:
128.79000

[ LogP ]:
5.94590

[ Index of Refraction ]:
1.737

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Improvement and biological applications of fluorescent probes for zinc, ZnAFs.

J. Am. Chem. Soc. 124 , 6555-6562, (2002)

The development and cellular applications of novel fluorescent probes for Zn2+, ZnAF-1F, and ZnAF-2F are described. Fluorescein is used as a fluorophore of ZnAFs, because its excitation and emission w...

Hirano, T., et al.

J. Am. Chem. Soc. 122 , 12399-12400 , (2000)