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(Tyr8)-Bradykinin

Names

[ CAS No. ]:
32222-00-7

[ Name ]:
(Tyr8)-Bradykinin

[Synonym ]:
BRADYKININ (TYR8)
Asp-Pro-Pro-Gly-Phe-Ser-Pro-Tyr-Arg
L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Tyr-L-Arg-OH
tyrosine8-bradykinin
Tyr8-bradykinin

Biological Activity

[Description]:

[Tyr8] Bradykinin is a B2 kinin receptor agonist. [Tyr8] Bradykinin also stimulates ERK1/2 phosphorylation. [Tyr8] Bradykinin can be used as an internal standard[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Endocrinology
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor
Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

Bradykinin B2 Receptor (B2R)

ERK1

ERK2


[In Vitro]

[Tyr8] Bradykinin (10 nM, 2 min) produces a rapid increase in phosphorylated ERK1/2[1]. Western Blot Analysis[1] Cell Line: Serum-deprived trabecular meshwork cells Concentration: 10 nM Incubation Time: 2 min Result: Produced a rapid increase in phosphorylated ERK1/2 that was equivalent in magnitude to that observed for Bradykinin (HY-P0206).

Chemical & Physical Properties

[ Molecular Formula ]:
C50H73N15O12

[ Molecular Weight ]:
1076.21000

[ Exact Mass ]:
1075.56000

[ PSA ]:
434.01000

[ LogP ]:
0.98690

Related Compounds