2-methyl-1-nitro-3-[[(3S)-oxolan-3-yl]methyl]guanidine

Names

[ Name ]:
2-methyl-1-nitro-3-[[(3S)-oxolan-3-yl]methyl]guanidine

[Synonym ]:
Guanidine,N-methyl-N'-nitro-N''-[[(3S)-tetrahydro-3-furanyl]methyl]

Biological Activity

[Description]:

(S)-Dinotefuran ((S)-MTI-446), a neonicotinoid pesticide, is toxic by binding to α8 subunit of nAChR of honeybee Apis mellifera (Apis mellifera Linnaeus). (S)-Dinotefuran shows more toxic than R-dinotefuran to honeybee Apis mellifera[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

[References]

[1]. Zenglong Chen, et al. Ecological toxicity reduction of dinotefuran to honeybee: New perspective from an enantiomeric level. Environ Int. 2019 Sep;130:104854.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₄N₄O₃

[ Molecular Weight ]:
202.21100

[ Exact Mass ]:
202.10700

[ PSA ]:
91.47000

[ LogP ]:
0.68460