Sabiporide hydrochloride

Names

[ CAS No. ]:
324758-66-9

[ Name ]:
Sabiporide hydrochloride

[Synonym ]:
Sabiporide
UNII-U52APA00X7
Sabiporide HCl

Biological Activity

[Description]:

Sabiporide hydrochloride is a NHE-1 inhibitor (Ki: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Neurological Disease

[References]

[1]. Touret N, et al. Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. Eur J Pharmacol. 2003 Jan 17;459(2-3):151-8.  

[2]. Park HS, et al. Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia. Brain Res. 2005 Nov 2;1061(1):67-71.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19F3N6O2

[ Molecular Weight ]:
408.37800

[ Exact Mass ]:
408.15200

[ PSA ]:
121.80000

[ LogP ]:
2.99690