Nicarbazin

Names

[ CAS No. ]:
330-95-0

[ Name ]:
Nicarbazin

[Synonym ]:
EINECS 206-359-1
Nirazin
Nicarbazine
Nicrazin
Nicarbazin
Nicarb
Nicrazine
Nicoxin
Nicarbasin
N,N'-bis(4-Nitrophenyl)urea compound with 4,6-dimethyl-2-pyrimidinone
MK 75

Biological Activity

[Description]:

Nicarbazin is an effective anticoccidial agent for chickens[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vivo]

Nicarbazin does not adversely affect the development of immunity or resistance to re-infection with E. acervulina oocysts[1].

[References]

[1]. Ott, W. H., et al. Biological Studies on Nicarbazin, a New Anticoccidial Agent. Poultry Science. 1956. 35(6), 1355–1367.

[2]. CUCKLER AC, et al. The effect of nicarbazin on the development of immunity to avian coccidia. J Parasitol. 1956 Dec;42(6):593-607.

Chemical & Physical Properties

[ Density]:
1.4663 (rough estimate)

[ Boiling Point ]:
414.8ºC at 760 mmHg

[ Melting Point ]:
265-275ºC

[ Molecular Formula ]:
C₁₉H₁₈N₆O₆

[ Molecular Weight ]:
426.383

[ Flash Point ]:
204.7ºC

[ Exact Mass ]:
426.128784

[ PSA ]:
178.78000

[ LogP ]:
5.13840

[ Index of Refraction ]:
1.6000 (estimate)

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
DMSO: soluble0.5mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
FE0900000

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea.

Food. Addit. Contam. Part. B. Surveill. 8 , 106-12, (2015)

The Korean National Residue Programme comprises three different approaches for evaluating domestic and imported foods of animal origin: monitoring, surveillance/enforcement and an exploratory test pro...

Sensitivity of Eimeria field isolates in the United States: responses of nicarbazin-containing anticoccidials.

Poult. Sci. 87(9) , 1760-7, (2008)

A series of studies were conducted to assess the drug sensitivity of 26 coccidial field isolates to the anticoccidial effects of nicarbazin (NIC) and narasin + NIC (NAR + NIC). Isolates were collected...

Evaluation of nicarbazin as a potential waterfowl contraceptive using mallards as a model.

Poult. Sci. 85(7) , 1275-84, (2006)

Contraception may provide a useful nonlethal management tool to reduce wild bird populations. We tested the efficacy of nicarbazin (NCZ) as a contraceptive for waterfowl and assessed health effects of...