TN-16

Names

[ CAS No. ]:
33016-12-5

[ Name ]:
TN-16

[Synonym ]:
2,3`-ANHYDROTHYMIDINE-D3
3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione

Biological Activity

[Description]:

TN-16 is a potent inhibitor of microtubule polymerization with IC50 of 0.4-1.7 µM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. Arai T. Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug. FEBS Lett. 1983 May 8;155(2):273-6.

Chemical & Physical Properties

[ Density]:
1.249g/cm3

[ Boiling Point ]:
532.7ºC at 760 mmHg

[ Melting Point ]:
182-185 °C

[ Molecular Formula ]:
C₁₉H₁₈N₂O₂

[ Molecular Weight ]:
306.35800

[ Flash Point ]:
195.5ºC

[ Exact Mass ]:
306.13700

[ PSA ]:
58.20000

[ LogP ]:
3.08450

[ Index of Refraction ]:
1.648

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H400

[ Precautionary Statements ]:
P273-P280

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
43-50/53

[ Safety Phrases ]:
36/37-60-61

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.

J. Cell Sci. 128 , 4572-87, (2015)

Although it is generally accepted that chromatin containing the histone H3 variant CENP-A is an epigenetic mark maintaining centromere identity, the pathways leading to the formation and maintenance o...

Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug.

FEBS Lett. 155(2) , 273-6, (1983)

An antitumor drug, 3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16) inhibited the assembly of porcine brain microtubules in vitro. The assembly induced by taxol was also suppressed by the...

Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity.

Biochem. Biophys. Res. Commun. 296(2) , 328-36, (2002)

Fas ligand (FasL) has been implicated in cytotoxic T lymphocyte (CTL)- and natural killer (NK) cell-mediated cytotoxicity. In the present study, we investigated the localization of FasL in murine CTL ...