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Ibrutinib deacryloylpiperidine

Names

[ CAS No. ]:
330786-24-8

[ Name ]:
Ibrutinib deacryloylpiperidine

[Synonym ]:
3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-
3-(4-Phenoxyphenyl)-1H-pyrazolo(3,4d)pyrimidin-4-amine
5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine
Ibrutinib Impurity 8

Biological Activity

[Description]:

Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[References]

[1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.

[2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
577.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H13N5O

[ Molecular Weight ]:
303.318

[ Flash Point ]:
303.0±30.1 °C

[ Exact Mass ]:
303.112000

[ PSA ]:
89.71000

[ LogP ]:
3.01

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.734

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds