sRANKL-IN-1

Names

[ CAS No. ]:
331968-10-6

[ Name ]:
sRANKL-IN-1

Biological Activity

[Description]:

sRANKL-IN-1 (compound S3) is a sRANKL (soluble RANKL) inhibitor. sRANKL-IN-1 shows a potent osteoclast inhibition effect with an IC50 value of 0.096 μM and a KD value of 34.80 μM. sRANKL-IN-1 can be used for the research of osteoporosis[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.096 μM (osteoclast)[1]


[In Vitro]

sRANKL-IN-1 (0-50 μM) shows potent inhibition to osteoclast[1]. Cell Viability Assay[1] Cell Line: Bone marrow cell line Concentration: 0-50 μM Incubation Time: Until osteoclasts formed Result: Inhibited osteoclasts formation with an IC50 value of 0.096 μM and a KD value of 34.80 μM.

[References]

[1]. Huang D, et al. Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis. Nat Commun. 2022 Sep 12;13(1):5338.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H18N4O6S

[ Molecular Weight ]:
418.42

Related Compounds