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1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one

Names

[ CAS No. ]:
332371-82-1

[ Name ]:
1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one

[Synonym ]:
4,6-Heptadien-3-one, 1,7-bis(4-hydroxyphenyl)-, (4E,6E)-
(4E,6E)-1,7-Bis(4-hydroxyphenyl)-4,6-heptadien-3-one

Biological Activity

[Description]:

1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 µM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 2) (1-10 µM) inhibits melanogenesis in B16 melanoma 4A5 cells with an IC50 of 1.99 µM[2].

[References]

[1]. Ali MS, et al. Six new diarylheptanoids from the seeds of Alpinia blepharocalyx. J Nat Prod. 2001 Mar;64(3):289-93.

[2]. Matsumoto T, et al. Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
542.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H18O3

[ Molecular Weight ]:
294.34

[ Flash Point ]:
295.7±25.2 °C

[ Exact Mass ]:
294.125580

[ PSA ]:
57.53000

[ LogP ]:
2.89

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.648

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds