Amino-PEG7-amine

Names

[ CAS No. ]:
332941-25-0

[ Name ]:
Amino-PEG7-amine

[Synonym ]:
2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine

Biological Activity

[Description]:

Amino-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₃₆N₂O₇

[ Molecular Weight ]:
368.46600

[ Exact Mass ]:
368.25200

[ PSA ]:
116.65000

[ LogP ]:
0.42060

[ Storage condition ]:
2-8°C

Amino-PEG7-amine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds