Safrazine

Names

[ Name ]:
Safrazine

[Synonym ]:
[3-(1,2,3-triphenylcyclopropenyl)]-9'-cyanofluorene
9H-Fluorene-9-carbonitrile,9-(1,2,3-triphenyl-2-cyclopropen-1-yl)
[3-(1,3-benzodioxol-5-yl)-1-methyl-propyl]hydrazine
1-methyl-3-(3,4-methylenedioxyphenyl)propylhydrazine
1-Piperonyl-2-hydrazinopropan

Biological Activity

[Description]:

Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[In Vitro]

Safrazine (0.1-0.5 μM; 0-80 min) strengthenes the inhibitory potency by preincubation in a time-dependent manner[1].

[In Vivo]

Safrazine (oral; 3, 10, 30 mg/kg) causes the increases contents of monoamine lasted for at least 24 h[1]. Safrazine strongly inhibits both 5-HT and PEA deaminations, but shows no selectivity toward the substrate used[1]. Animal Model: Male ddY mice[1] Dosage: 3, 10, 30 mg/kg Administration: Oral Result: Inhibited significantly both 5-HT and PEA deaminations at only 3 mg/kg by 77% and 71%, respectively. Completely reduced both deaminations at 10 and 30 mg/kg and not observed specificity toward substrates.

Chemical & Physical Properties

[ Density]:
1.161g/cm3

[ Boiling Point ]:
368.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₆N₂O₂

[ Molecular Weight ]:
208.25700

[ Flash Point ]:
176.9ºC

[ Exact Mass ]:
208.12100

[ PSA ]:
56.51000

[ LogP ]:
2.29090

[ Vapour Pressure ]:
1.24E-05mmHg at 25°C

[ Index of Refraction ]:
1.563

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%