3-(pyridin-2-ylmethylidene)-1H-indol-2-one

Names

[ Name ]:
3-(pyridin-2-ylmethylidene)-1H-indol-2-one

Biological Activity

[Description]:

(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Research Areas >> Metabolic Disease

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[References]

[1]. Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817.

Chemical & Physical Properties

[ Density]:
1.291g/cm3

[ Boiling Point ]:
457.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₀N₂O

[ Molecular Weight ]:
222.24200

[ Flash Point ]:
230.3ºC

[ Exact Mass ]:
222.07900

[ PSA ]:
41.99000

[ LogP ]:
2.71230

[ Index of Refraction ]:
1.693

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933790090

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%