8-Nitro-D-guanosine

Names

[ Name ]:
8-Nitro-D-guanosine

[Synonym ]:
2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-nitro-3H-purin-6-one

Biological Activity

[Description]:

8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₂N₆O₇

[ Molecular Weight ]:
328.24

[ Exact Mass ]:
328.07700

[ PSA ]:
205.33000

8-Nitro-D-guanosine

Names

Biological Activity

Chemical & Physical Properties

Related Compounds