N-[5-(2-methoxyethoxy)-2-pyrimidinyl]benzenesulphonamide

Names

[ CAS No. ]:
339-44-6

[ Name ]:
N-[5-(2-methoxyethoxy)-2-pyrimidinyl]benzenesulphonamide

[Synonym ]:
Glycodiazin
Glycodiazin [German]
EINECS 206-426-5
N-[5-(2-methoxy-ethoxy)-pyrimidin-2-yl]-benzenesulfonamide
GLYMIDINE
UNII-4C5I4BQZ8F
Glymidinum
Glycodiazine
Glidiazine

Biological Activity

[Description]:

Glymidine (Glidiazine) is a hypoglycaemic agent. Glymidine is a lipid soluble sulphapyrimidine derivative. Glymidine appears to stimulate insulin release from pancreas. Glymidine is a possible alternative to the sulphonylureas and biguanides for the research of diabetes mellitus[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Glymidine. Br Med J. 1967;2(5555):817.

Chemical & Physical Properties

[ Density]:
1.354g/cm3

[ Boiling Point ]:
515.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₅N₃O₄S

[ Molecular Weight ]:
309.34100

[ Flash Point ]:
265.4ºC

[ Exact Mass ]:
309.07800

[ PSA ]:
98.79000

[ LogP ]:
2.45640

[ Index of Refraction ]:
1.588

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB2910000

CHEMICAL NAME :: Benzenesulfonamide, N-(5-(2-methoxyethoxy)-2-pyrimidinyl)-

CAS REGISTRY NUMBER :: 339-44-6

BEILSTEIN REFERENCE NO. :: 0552655

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H15-N3-O4-S

MOLECULAR WEIGHT :: 309.37

WISWESSER LINE NOTATION :: T6N CNJ BMSWR& EO201

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Endocrine - hypoglycemia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,377,1964

Safety Information

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%