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clocortolone pivalate

Names

[ CAS No. ]:
34097-16-0

[ Name ]:
clocortolone pivalate

[Synonym ]:
(6α,11β,16α)-9-chloro-6-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,2-dimethylpropanoate
9-Chloro-6a-fluoro-11b,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-Pivalate
Pregna-1,4-diene-3,20-dione, 9-chloro-21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methyl-, (6α,11β,16α)-
Purantix
(6α,11β,16α)-9-Chloro-6-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pivalate
CLODERM
CL 68
(6a,11b,16a)-9-Chloro-21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
clocortolone pivalate
Clocortolone 21-pivalate
9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate
SH-863
Propanoic acid, 2,2-dimethyl-, (6α,11β,16α)-9-chloro-6-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl ester
Clocortolone triMethylacetate
9α-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-pivalate

Biological Activity

[Description]:

Clocortolone pivalate is a synthetic glucocorticoid corticosteroid and corticosteroid ester. Clocortolone pivalate is indicated for seborrheic dermatitis, contact dermatitis, atopic dermatitis and psoriasis[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Kircik LH, et al. The treatment of inflammatory facial dermatoses with topical corticosteroids: focus on clocortolone pivalate 0.1% cream. J Drugs Dermatol. 2012 Oct;11(10):1194-8.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
598.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H36ClFO5

[ Molecular Weight ]:
495.023

[ Flash Point ]:
315.4±30.1 °C

[ Exact Mass ]:
494.223541

[ PSA ]:
80.67000

[ LogP ]:
4.36

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.552

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds