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PNU-248686A

Names

[ CAS No. ]:
341498-89-3

[ Name ]:
PNU-248686A

[Synonym ]:
Sodium (2R)-3-[(4'-chloro-4-biphenylyl)sulfonyl]-2-hydroxy-2-[(phenylsulfanyl)methyl]propanoate
Propanoic acid, 3-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]-2-hydroxy-2-[(phenylthio)methyl]-, sodium salt, (2R)- (1:1)

Biological Activity

[Description]:

PNU-248686A is a novel matrix metalloproteinase (MMP) inhibitor.

[Related Catalog]:

Research Areas >> Cancer

[Target]

MMP[1]


[In Vitro]

PNU-248686A is an orally active matrix metalloproteinase (MMP) inhibitor developed for the treatment of solid tumors over-expressing MMPs[1].

[References]

[1]. Frigerio E, et al. Determination of PNU-248686A, a novel matrix metalloproteinase inhibitor, in human plasma by liquid chromatography-tandem mass spectrometry, following protein precipitation in the 96-well plate format. J Chromatogr A. 2003 Feb 14;987(1-2):249-56.


[Related Small Molecules]

GM 6001 | T-5224 | SB-3CT | Batimastat | Astragaloside IV | Marimastat (BB-2516) | edaravone | TAPI-2 | TAPI 1 | ISOGINKGETIN | Arctigenin | CTS-1027 | GI254023X | JNJ 0966 | CL-82198

Chemical & Physical Properties

[ Molecular Formula ]:
C22H19ClNaO5S2

[ Molecular Weight ]:
485.96

[ Storage condition ]:
2-8℃

Related Compounds