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NH2-PEG5-OH

Names

[ CAS No. ]:
34188-11-9

[ Name ]:
NH2-PEG5-OH

[Synonym ]:
14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
MFCD28950782
3,6,9,12-Tetraoxatetradecan-1-ol, 14-amino-

Biological Activity

[Description]:

NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.

[2]. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.

Chemical & Physical Properties

[ Density]:
1.1±0.0 g/cm3

[ Boiling Point ]:
346.3±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H23NO5

[ Molecular Weight ]:
237.293

[ Flash Point ]:
163.2±0.0 °C

[ Exact Mass ]:
237.157623

[ LogP ]:
-2.44

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.460

[ Storage condition ]:
2-8°C

Related Compounds