2'-O-Methyl-5-Iodo-Uridine

Names

[ Name ]:
2'-O-Methyl-5-Iodo-Uridine

[Synonym ]:
2'-OMe-5-I-Uridine
5-Iodo-2'-O-methyluridin
5-IODO-2'-O-METHYLURIDINE
2'-OMe-5-I-U
Uridine,5-iodo-2'-O-Methyl
2'-O-Methyl-5-Iodo-Uridine

Biological Activity

[Description]:

2’-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.04±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C₁₀H₁₃IN₂O₆

[ Molecular Weight ]:
384.12

[ Exact Mass ]:
383.98200

[ PSA ]:
113.78000

[ Storage condition ]:
2-8℃

2'-O-Methyl-5-Iodo-Uridine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds