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NS 3623

Names

[ CAS No. ]:
343630-41-1

[ Name ]:
NS 3623

Biological Activity

[Description]:

NS3623 is a hERG (KV11.1) and KV4.3 channel activator. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect[1][2].

[References]

[1]. Hansen RS, et al. In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41.

[2]. Diness JG, et al. Antiarrhythmic effect of IKr activation in a cellular model of LQT3. Heart Rhythm. 2009 Jan;6(1):100-6.

[3]. Calloe K, et al. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem Pharmacol. 2016 May 15;108:36-46.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₀BrF₃N₆O

[ Molecular Weight ]:
427.17900

[ Exact Mass ]:
426.00500

[ PSA ]:
99.08000

[ LogP ]:
4.37860

Related Compounds