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N1-Acetylspermidine hydrochloride

Names

[ CAS No. ]:
34450-16-3

[ Name ]:
N1-Acetylspermidine hydrochloride

[Synonym ]:
Acetamide, N-[3-[(4-aminobutyl)amino]propyl]-, dihydrochloride
N1-Acetylspermidine (hydrochloride)

Biological Activity

[Description]:

N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84.

[2]. Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44(2):845-7.

[3]. Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H23Cl2N3O

[ Molecular Weight ]:
223.74300

[ Exact Mass ]:
223.14500

[ PSA ]:
67.15000

[ LogP ]:
2.12520

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds