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Cetirizine Impurity D

Names

[ CAS No. ]:
346451-15-8

[ Name ]:
Cetirizine Impurity D

[Synonym ]:
MFCD03844641

Biological Activity

[Description]:

Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Endocrinology
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055-1080, 1993.

[2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5.

[3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.

Chemical & Physical Properties

[ Boiling Point ]:
270-275℃(Press: 1 Torr)

[ Molecular Formula ]:
C30H30Cl4N2

[ Molecular Weight ]:
560.38500

[ Exact Mass ]:
558.11600

[ PSA ]:
6.48000

[ LogP ]:
8.96980

Related Compounds