AMP-PCP

Names

[ CAS No. ]:
3469-78-1

[ Name ]:
AMP-PCP

[Synonym ]:
β,γ-methylene ATP
beta,gamma-methylene-ATP
AMP-PCP
β,γ-methylene-ATP
β,γ-meATP
adenosine-5’-[(β,γ)-methyleno]triphosphate

Biological Activity

[Description]:

AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

HSP90:3.8 μM (Kd)


[In Vitro]

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].

[References]

[1]. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.

Chemical & Physical Properties

[ Molecular Formula ]:
C11H18N5O12P3

[ Molecular Weight ]:
505.20800

[ Exact Mass ]:
505.01600

[ PSA ]:
299.33000

Related Compounds