Desferrichrome

Names

[ Name ]:
Desferrichrome

[Synonym ]:
Ferrichrome Iron-free
4b8y
Desferrichrome
Desferriferrichrome
Deferriferrichrome
N-Dffc
N-Desferriferrichrome
Deferrichrome
Ferrichrome,deferri

Biological Activity

[Description]:

Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be used as a heterosiderophore by bacteria, including Pseudomonas aeruginosa and Vibrio parahaemolyticus. Ferrichrome (0.8 μM) inhibits concanavalin A-induced proliferation of mouse spleen monocytes and reduces the number of concanavalin A-stimulated CD4+ T cells expressing IL-2 receptor. It also inhibits the heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₄₅N₉O₁₂

[ Molecular Weight ]:
687.69900

[ Exact Mass ]:
687.31900

[ PSA ]:
317.16000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Microbial iron compounds.

Annu. Rev. Biochem. 50 , 715, (1981)

The biodistribution of 67Ga-labelled N-hydroxyamino acid derivatives in tumour-bearing rats.

Nucl. Med. Commun. 7(1) , 53-7, (1986)

The biodistribution of 67Ga-labelled complexes of some mono- and di-N-hydroxyamino acid derivatives and of two siderophores (trihydroxamates) were evaluated in Rhabdomyosarcoma-bearing rats. It was fo...

The solution conformations of ferrichrome and deferriferrichrome determined by 1H-NMR spectroscopy and computational modeling.

Biopolymers 30(3-4) , 239-56, (1990)

We have applied computational procedures that utilize nmr data to model the solution conformation of ferrichrome, a rigid microbial iron transport cyclohexapeptide of known x-ray crystallographic stru...