Ceefourin 2

Names

[ Name ]:
Ceefourin 2

[Synonym ]:
3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 3-chloro-5-(4-methylphenyl)-7-(trifluoromethyl)-

Biological Activity

[Description]:

Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Cheung L, et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem Pharmacol. 2014 Sep 1;91(1):97-108.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₅H₉ClF₃N₃O₂

[ Molecular Weight ]:
355.70

[ Exact Mass ]:
355.033539

[ LogP ]:
3.03

[ Index of Refraction ]:
1.630