GTP 14564

Names

[ Name ]:
GTP 14564

[Synonym ]:
3-Phenyl-1H-benzofuro<3,2-c>pyrazol

Biological Activity

[Description]:

GTP-14564 is a tyrosine kinase inhibitor targeting to internal tandem duplication (ITD) and FLT3. GTP-14564 inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

[References]

[1]. Murata K, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003 Aug 29;278(35):32892-8.

Chemical & Physical Properties

[ Density]:
1.321g/cm3

[ Boiling Point ]:
459.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₁₀N₂O

[ Molecular Weight ]:
234.25

[ Flash Point ]:
240.7ºC

[ Exact Mass ]:
234.07900

[ PSA ]:
41.82000

[ LogP ]:
3.97610

[ Index of Refraction ]:
1.738

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%