UK 383367

Names

[ Name ]:
UK 383367

[Synonym ]:
CS-0414
UK383367
1,2,4-Oxadiazole-5-propanamide, 3-(aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-, (βR)-
S2224_Selleck
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
UK 383367
5-[(3R)-6-Cyclohexyl-1-(hydroxyamino)-1-oxo-3-hexanyl]-1,2,4-oxadiazole-3-carboxamide
UK-383367

Biological Activity

[Description]:

UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).IC50 value: 44 nMTarget: procollagen C-proteinaseUK-383367 (UK 383367) is useful for anti-scarring agent

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Procollagen C Proteinase

Research Areas >> Others

[References]

[1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418.

[2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Melting Point ]:
136-138℃

[ Molecular Formula ]:
C₁₅H₂₄N₄O₄

[ Molecular Weight ]:
324.375

[ Exact Mass ]:
324.179749

[ PSA ]:
134.83000

[ LogP ]:
1.37

[ Appearance of Characters ]:
white to off-white

[ Index of Refraction ]:
1.541

[ Storage condition ]:
Store at -20°C

[ Water Solubility ]:
DMSO: >30mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
UN 2811 6.1 / PGIII