JX-401

Names

[ Name ]:
JX-401

[Synonym ]:
1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine
JX401

Biological Activity

[Description]:

JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Research Areas >> Inflammation/Immunology

[References]

[1]. Friedmann Y, et al. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol Pharmacol. 2006;70(4):1395-1405.

Chemical & Physical Properties

[ Density]:
1.17g/cm3

[ Boiling Point ]:
537.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₅NO₂S

[ Molecular Weight ]:
355.49400

[ Flash Point ]:
278.8ºC

[ Exact Mass ]:
355.16100

[ PSA ]:
54.84000

[ LogP ]:
4.44990

[ Index of Refraction ]:
1.611

MSDS

Click to get detail MSDS

Safety Information

[ Risk Phrases ]:
R50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077 9/PG 3