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7ß-Hydroxycholesterol-d7

Names

[ CAS No. ]:
349553-97-5

[ Name ]:
7ß-Hydroxycholesterol-d7

[Synonym ]:
7-Hydroxy Cholesterol-d7
(3S,7R,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-5-methyl-2-hexanyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol (non-preferred name)
5-Cholestene-3,7-diol-d7
Cholest-5-ene-3,7-diol-d7
7-Hydroxycholest-5-en-3-ol-d7

Biological Activity

[Description]:

7ß-Hydroxycholesterol-d7 is the deuterium labeled 7α-Hydroxycholesterol. 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Anne Vejux, et al. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
503.4±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H39D7O2

[ Molecular Weight ]:
409.70

[ Flash Point ]:
211.8±21.4 °C

[ Exact Mass ]:
388.334137

[ PSA ]:
40.46000

[ LogP ]:
7.41

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.539

Related Compounds