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2-Thiodeoxyuridine

Names

[ CAS No. ]:
35059-12-2

[ Name ]:
2-Thiodeoxyuridine

[Synonym ]:
5′-Acetyl-2′,3′-isopropylideneadenosine
5'-O-Acetyl-2',3'-O-isopropylideneadenosine
5'-ACETYL-2',3'-ISOPROPYLIDENEADENOSINE
Adenosine, 2',3'-O-(1-methylethylidene)-, 5'-acetate

Biological Activity

[Description]:

2′-Deoxy-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
562.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H12N2O4S

[ Molecular Weight ]:
244.27

[ Flash Point ]:
293.8±32.9 °C

[ Exact Mass ]:
349.138611

[ LogP ]:
1.61

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.730

Related Compounds