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OGG1-IN-08

Names

[ CAS No. ]:
350997-39-6

[ Name ]:
OGG1-IN-08

[Synonym ]:
Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide
3,4-Dichloro-1-benzothiophene-2-carbohydrazide

Biological Activity

[Description]:

OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.22 μM (OGG1)[1]


[In Vitro]

OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively[1]. OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control[1]. OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor[1].

[References]

[1]. Nathan Donley,et al. Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol. 2015 Oct 16;10(10):2334-43.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C9H6Cl2N2OS

[ Molecular Weight ]:
261.128

[ Exact Mass ]:
259.957794

[ LogP ]:
2.34

[ Index of Refraction ]:
1.718

Related Compounds