blasticidin s hydrochloride

Names

[ Name ]:
blasticidin s hydrochloride

[Synonym ]:
MFCD02091640
Blasticidine S hydrochloride
BlasticidinS,monohydrochloride (8CI)
Blasticidin S hydrochloride

Biological Activity

[Description]:

Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Blasticidin S (BlaS) is a broad spectrum antibiotic and inhibits cell growth in prokaryotes, fungi, plants, and mammalian cells[1].

[References]

[1]. Kitamura K, et al. Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):393-398.

Chemical & Physical Properties

[ Boiling Point ]:
772.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₇ClN₈O₅

[ Molecular Weight ]:
458.90

[ Flash Point ]:
420.8ºC

[ Exact Mass ]:
458.17900

[ PSA ]:
215.67000

[ LogP ]:
1.05570

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in water. Insoluble in organic solvents.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300

[ Precautionary Statements ]:
P264-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R28

[ Safety Phrases ]:
28-36/37-45

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

Articles

A rice fungicide blasticidin S efficiently binds Cu(II) ions and prevents DNA from metal-induced damage.

J. Inorg. Biochem. 127 , 73-8, (2013)

Blasticidin S is a representative of the aminoacylnucleoside class of antibiotics and it possesses fungicidal properties against the virulent fungus which causes a serious rice blast disease in Asia. ...

Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome.

Proc. Natl. Acad. Sci. U. S. A. 110(30) , 12283-8, (2013)

The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and...

Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.

Proc. Natl. Acad. Sci. U. S. A. 103 , 13485-13490, (2006)

Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and rel...