Tetraphenylporphyrin Tetrasulfonic Acid Hydrate

Names

[ Name ]:
Tetraphenylporphyrin Tetrasulfonic Acid Hydrate

[Synonym ]:
tetraphenylporphinesulfonate
MFCD00070632
tpps4
(Tetraphenylporphyrin Tetrasulfonic Acid Hydrate)
4,4',4'',4'''-(5,10,15,20-Porphyrintetrayl)tetrabenzenesulfonic acid
Benzenesulfonic acid, 4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-
meso-Tetraphenylporphine-4,4',4
meso-tetraphenylporphine-4,4',4'',4'''-tetrasulfonic acid
TSPP
5,10,15,20-Tetrakis(4-sulfophenyl)porphyrin Hydrate
5,10,15,20-tetraphenyl-21H,23H-perphine-4,4',4'',4'''-tetrasulfonic acid
4,4',4'',4'''-porphyrin-5,10,15,20-tetrayltetrabenzenesulfonic acid

Biological Activity

[Description]:

TPPS can be used as a non-cytotoxic probe for detecting tumor location[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

TPPS (0-20 μg/mL) shows no toxicity in Vero and HEp-2 cells in vitro and predominantly locates in the soluble and protein fractions in cells[1].

[In Vivo]

TPPS4 shows the highest tumor to tissue ratios after 96 hours injection with a dose dependent manner[2]. TPPS4 appears to be cleared through the kidneys and absolute concentrations there are reduced with increasing time after injection[2].

[References]

[1]. Austen JD, et al. Intracellular localization of meso-Tetra(p-sulfophenyl)porphine: a potential tumor localizing agent. Cancer Treat Rep. 1978 Apr;62(4):511-8.

[2]. https://pubmed.ncbi.nlm.nih.gov/201378/

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₄₄H₃₀N₄O₁₂S₄

[ Molecular Weight ]:
934.989

[ Exact Mass ]:
934.074280

[ PSA ]:
307.30000

[ LogP ]:
5.01

[ Index of Refraction ]:
1.724

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DB7339000

Synthetic Route

Click to get detail synthetic route

Articles

Femtosecond to second studies of a water-soluble porphyrin derivative in chemical and biological nanocavities.

Langmuir 28(9) , 4363-72, (2012)

The interactions of 5,10,15,20-tetrakis(4-sulfonatophenyl)-porphyrin (TSPP) with a quaternary ammonium modified β-cyclodextrin (QA-β-CD) and human serum albumin (HSA) protein in aqueous solutions at p...

Preferential solvation and solvation shell composition of free base and protonated 5, 10, 15, 20-tetrakis(4-sulfonatophenyl)porphyrin in aqueous organic mixed solvents.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 83(1) , 213-20, (2011)

The solvatochromic properties of the free base and the protonated 5, 10, 15, 20-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) were studied in pure water, methanol, ethanol (protic solvents), dimethylsul...

Interaction of monosulfonate tetraphenyl porphyrin (H2TPPS1) with plant-esterase: determination of the binding mechanism by spectroscopic methods.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 78(5) , 1349-55, (2011)

The interaction of monosulfonate tetraphenyl porphyrin (H(2)TPPS(1)) with plant-esterase was investigated using fluorescence and UV-vis absorption spectroscopy. Fluorescence quenching, from which the ...