SIRT1-IN-1

Names

[ Name ]:
SIRT1-IN-1

Biological Activity

[Description]:

SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM[1]. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity[2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Signaling Pathways >> Anti-infection >> CMV

[Target]

SIRT1:0.205 μM (IC50)

SIRT2:11.5 μM (IC50)

SIRT3:>100 μM (IC50)

[In Vitro]

SIRT1-IN-1 (compound 2) has little effect on SIRT3 (IC50>100 μM) and HDAC (IC50>100 μM)[1].

[References]

[1]. Andrew D Napper, et al. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.

[2]. Thomas Shenk, et al. Sirtuin Modulators as Inhibitors of Cytomegalovirus. US20160296523A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₆N₂O

[ Molecular Weight ]:
228.29

SIRT1-IN-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds