Protein kinase G inhibitor-1

Names

[ Name ]:
Protein kinase G inhibitor-1

[Synonym ]:
MFCD01342041
Benzo[b]thiophene-3-carboxamide, 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-6-methyl-
2-[(Cyclopropylcarbonyl)amino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

Biological Activity

[Description]:

Protein kinase G inhibitor-1 (Compound 270) is a mycobacterial protein kinase G inhibitor, with an IC50 of 0.9 μM. Protein kinase G inhibitor-1 can be used for mycobacterial infection research[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

0.9 μM (mycobacterial protein kinase G)[1]

[References]

[1]. Missio Andrea, et al. 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and methods for medical intervention against mycobacterial infections. Patent. WO2003084947. 2003-10-16.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
464.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₈N₂O₂S

[ Molecular Weight ]:
278.37

[ Flash Point ]:
234.9±28.7 °C

[ Exact Mass ]:
278.108887

[ LogP ]:
2.97

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.660