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11-deoxy Prostaglandin E2

Names

[ CAS No. ]:
35536-53-9

[ Name ]:
11-deoxy Prostaglandin E2

[Synonym ]:
11-Deoxy-PGE2
(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,13-dien-1-oic acid
Prosta-5,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-

Biological Activity

[Description]:

11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC50 of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[References]

[1]. Holt MC, et al. Improved homology modeling of the human & rat EP4 prostanoid receptors. BMC Mol Cell Biol. 2019 Aug 27;20(1):37.  

[2]. Ungrin MD, et al. Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor. Mol Pharmacol. 2001 Jun;59(6):1446-56.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
510.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H32O4

[ Molecular Weight ]:
336.47

[ Flash Point ]:
276.5±25.2 °C

[ Exact Mass ]:
336.230072

[ PSA ]:
74.60000

[ LogP ]:
3.41

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.543

Related Compounds