Cyclo(L-Phe-L-Val)

Names

[ Name ]:
Cyclo(L-Phe-L-Val)

[Synonym ]:
Cyclo(Val-Phe)
(3S,6S)-3-isopropyl-6-benzylpiperazine-2,5-dione
(3S,6S)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione
cyclo(L-phenylalanyl-L-valine)
(S,S)-cyclo-Val-Phe
(3S,6S)-3-benzyl-6-isopropyl-2,5-piperazinedione

Biological Activity

[Description]:

Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[Target]

Isocitrate lyase (ICL)[1]

[In Vitro]

Cyclo(L-Phe-L-Val) (32 μg/mL; 2 d) 分别降低白色念珠菌 SC5314 (野生型)、MRC10 (Δicl) 和 MRC11 (Δicl + ICL) 中的 icl 产物水平[1]。

[References]

[1]. Kim H, et al. Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans. Molecules. 2019 Jun 4;24(11):2111.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₈N₂O₂

[ Molecular Weight ]:
246.30

[ Exact Mass ]:
246.13700

[ PSA ]:
58.20000

[ LogP ]:
1.52590

Cyclo(L-Phe-L-Val)

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds