Deoxylapachol

Names

[ Name ]:
Deoxylapachol

[Synonym ]:
2-(3-methylbut-2-en-1-yl)naphthalene-1,4-dione
2-prenyl-1,4-naphthoquinone
DESOXYLAPACHOL
deoxylapachol
1,4-Naphthalenedione, 2-(3-methyl-2-buten-1-yl)-
2-(3-Methyl-2-buten-1-yl)-1,4-naphthoquinone
2-deoxylapachol
1,4-naphthalenedione, 2-(3-methyl-2-butenyl)-

Biological Activity

[Description]:

Deoxylapachol is a major cytotoxic component of New Zealand brown alga, Landsburgia quercifolia. Deoxylapachol has antifungal and anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Deoxylapachol is active against P-388 leukemia cells (IC50=0.6 microgm/ml).

[References]

[1]. N B Perry, et al. A cytotoxic and antifungal 1,4-naphthoquinone and related compounds from a New Zealand brown algae, Landsburgia quercifolia. J Nat Prod. Jul-Aug 1991;54(4):978-85.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
359.2±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₄O₂

[ Molecular Weight ]:
226.270

[ Flash Point ]:
134.8±24.9 °C

[ Exact Mass ]:
226.099380

[ PSA ]:
34.14000

[ LogP ]:
4.24

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.571

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2914690090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%