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Trimazosin

Names

[ CAS No. ]:
35795-16-5

[ Name ]:
Trimazosin

[Synonym ]:
trimazosine
TRIMAZOSIN
EINECS 252-732-7

Biological Activity

[Description]:

Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

α1-adrenergic receptor


[In Vivo]

Trimazosin (10–30 mg/kg; i.h.; once) produces graded decreases in blood pressure[3]. Animal Model: Conscious spontaneously hypertensive rats (SHR)[3] Dosage: 10–30 mg/kg Administration: Subcutaneous administration, once Result: Produced graded decreases in blood pressure.

[References]

[1]. J Vincent, et al. The cardiovascular effects of trimazosin and prazosin in the rabbit. Clin Exp Pharmacol Physiol. 1986 Aug;13(8):593-608.

[2]. H L Elliott, et al. Trimazosin in normotensive subjects. Clin Pharmacol Ther. 1984 Feb;35(2):156-60.

[3]. J. P. Buyniski, et al. Effects of Tiodazosin, Prazosin, Trimazosin and Phentolamine on Blood Pressure, Heart Rate and on Pre- and Postsynaptic α-Adrenergic Receptors in the Rat. Clinical and Experimental Hypertension , 1980, Vol.2(6), p.1039-1066.

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
648.2ºC at 760mmHg

[ Molecular Formula ]:
C20H29N5O6

[ Molecular Weight ]:
435.47

[ Flash Point ]:
345.8ºC

[ Exact Mass ]:
435.21200

[ PSA ]:
132.50000

[ LogP ]:
1.85140

[ Index of Refraction ]:
1.606

Related Compounds