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Urocortin III (human) trifluoroacetate salt

Names

[ CAS No. ]:
357952-09-1

[ Name ]:
Urocortin III (human) trifluoroacetate salt

Biological Activity

[Description]:

Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> CRFR
Research Areas >> Neurological Disease

[Target]

Ki: 13.5 (mCRF2β), 21.7 (rCRF2α), and >100 nM ( hCRF1)[1]


[In Vitro]

Urocortin III (human) (20 分钟；稳定表达克隆人 CRF-R1 或鼠 CRF-R2 的 CHO 细胞) 诱导细胞内 cAMP 积累[1]。

[References]

[1]. Lewis K, et, al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5.  

[2]. van der Meulen T, et, al. Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat Med. 2015 Jul;21(7):769-76.  

Chemical & Physical Properties

[ Molecular Formula ]:
C185H307N53O50S2

Related Compounds