Inosine 5'-triphosphate (sodium salt)

Names

[ Name ]:
Inosine 5'-triphosphate (sodium salt)

[Synonym ]:
Trisodium Inosine 5'-Triphosphate Hydrate
Inosine 5'-Triphosphate Trisodium Salt Hydrate
itp
INOSINE 5'-TRIPHOSPHATE SODIUM SALT
Inosine-5'-triphosphatetrisodiumsalt
ITP.Na3
Inosine 5'-triphosphate trisodium salt
INOSINE 5''-TRIPHOSPHATE SODIUM SALT HYDRATE
5'-ITP 3Na Hydrate
MFCD00084678
trisodium inosine 5'-triphosphate
ITP SODIUM SALT
Trisodium 5'-O-[({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphinato]inosine
5'-ITP 3Na
9H-Purin-6-ol, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-, sodium salt (1:3)
5'-ITPNa3

Biological Activity

[Description]:

Inosine-5'-triphosphate trisodium salt is a nucleoside triphosphate, functions as an substrate for ATPases and GTPases[1][2][3][4].

[References]

[1]. Hanson RL, et al. Energy-transducing adenosine triphosphatase from Escherichia coli: purification, properties, and inhibition by antibody. J Bacteriol. 1973 May;114(2):772-81.

[2]. Pieper U, et al. The GTP-binding domain of McrB: more than just a variation on a common theme? J Mol Biol. 1999 Sep 24;292(3):547-56.

[3]. Klinker JF, et al. Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes. Biochem Pharmacol. 1997 Sep 1;54(5):551-62.

[4]. Iuodka BA, et al. te specificity of T4 RNA-ligase: the role of a purine nucleotide base in forming a covalent AMP-RNA-ligase complex. Biokhimiia. 1993 Jun;58(6):857-65.

Chemical & Physical Properties

[ Density]:
2.63g/cm3

[ Boiling Point ]:
994.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₂N₄Na₃O₁₄P₃

[ Molecular Weight ]:
574.111

[ Flash Point ]:
555.5ºC

[ Exact Mass ]:
573.925598

[ PSA ]:
311.26000

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1.0

Articles

[Nucleoside-5'-triphosphate hydrolysis in the liver and kidney of rats with chronic alloxan diabetes].

Biomed. Khim. 52 , 364-369, (2006)

Activity and some properties of a soluble enzyme hydrolyzing nucleoside-5'-triphosphates were studied in the liver and kidney of normal and diabetic rats. The enzyme activity was shown to be reduced b...

Mapping interactions between the Ca2+-ATPase and its substrate ATP with infrared spectroscopy.

J. Biol. Chem. 278 , 10112-10118, (2003)

Infrared spectroscopy has been used to map substrate-protein interactions: the conformational changes of the sarcoplasmic reticulum Ca(2+)-ATPase upon nucleotide binding and ATPase phosphorylation wer...

Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis.

Structure 13 , 1511-1520, (2005)

Inosine triphosphate (ITP) and xanthosine triphosphate (XTP) are formed upon deamination of ATP and GTP as a result of exposure to chemical mutagens and oxidative damage. Nucleic acid synthesis requir...