Antiviral agent 23

Names

[ CAS No. ]:
35940-03-5

[ Name ]:
Antiviral agent 23

Biological Activity

[Description]:

Antiviral agent 23 (compound 11b) is an antiviral agent to enterovirus 71 (EV71) with an EC50 value of 94 nM. Antiviral agent 23 effectively suppresses the activity of METTL3/METTL14. Antiviral agent 23 can be used for the research of infection[1].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Antiviral agent 23 (0-100 μM) 抑制 CVA21 和 EV68 在 HeLa 细胞中的复制，其 EC50 值分别为 36.4 和 8.9 μM[1]。 Antiviral agent 23 (100 μM) 抑制 METTL3/METTL14 的酶活，至 74.45%[1]。 Antiviral agent 23 (0-100 μM) 抑制 EV71 毒株 BrCr 在 RD 细胞中的复制，EC50 值为 94 nM[1]。

[References]

[1]. Salerno M, et al. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. Eur J Med Chem. 2022 Nov 24;246:114942.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H21N5O4

[ Molecular Weight ]:
371.39

Related Compounds