Ganglioside GM2 Asialo Mixture

Names

[ Name ]:
Ganglioside GM2 Asialo Mixture

[Synonym ]:
MFCD00131129

Biological Activity

[Description]:

Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₆H₁₀₄N₂O₁₈

[ Molecular Weight ]:
1093.4

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Asialo GM-2 developed on the fatty streak of atherosclerotic aorta detected by a novel monoclonal antibody (ASH1a/256C).

Ann. N. Y. Acad. Sci. 748 , 277-81; discussion 281-2, (1995)

Catabolism of asialo-GM2 in man and mouse. Specificity of human/mouse chimeric GM2 activator proteins.

J. Biol. Chem. 274(40) , 28612-8, (1999)

Tay-Sachs disease is an inborn lysosomal disease characterized by excessive cerebral accumulation of GM2. The catabolism of GM2 to GM3 in man requires beta-hexosaminidase A (HexA) and a protein cofact...

Optimal conditions to radiolabel (3H or 14C) aminosugar-containing glycosphingolipids by de-N-acetylation and re-N-acetylation.

Biochim. Biophys. Acta 1244(2-3) , 418-22, (1995)

The optimal conditions were examined for selective re-N-acetylation with 14C or 3H.acetic anhydride of de-N-acetylated aminosugar-containing glycosphingolipids. Re-N-acetylation, which is nearly quant...