Diamfenetide

Names

[ Name ]:
Diamfenetide

[Synonym ]:
Diamfenetide
bis-[2-(4-acetylamino-phenoxy)-ethyl]-ether
diamphenethide
Coryphamin
Bis-[2-(4-acetylamino-phenoxy)-aethyl]-aether
N,N'-<Oxybis<2,1-(ethanediyloxy)-4,1-phenylene>>bisacetamide
Acemidophene
EINECS 252-886-5
Compound 68-198
Diamfenetidum [INN-Latin]
Diamfenetida [INN-Spanish]

Biological Activity

[Description]:

Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Diamfenetide (10-100 μM; 1-3 hours) treatment leads a time/dose-dependent, irreversible paralysis that involves an increase in muscular tension and decrease in contraction amplitude in vitro of immature and adult Fasciola hepatica[1]. Diamfenetide (100 μM; 6-24 hours) increases products of glucose metabolism by adult Fasciola hepatica in vitro. And the metabolic effects of Diamfenetide on F. hepatica may be secondary to the initial effects on surface membranes[2].

[References]

[1]. R S Rew, et al. Fasciola Hepatica: Effects of Diamfenetide Free Amine on in Vitro Physiology, Biochemistry, and Morphology. Exp Parasitol

[2]. R S Rew, et al. Effects of Diamfenetide on Metabolic and Excretory Functions of Fasciola Hepatica in Vitro. Comp Biochem Physiol C

Chemical & Physical Properties

[ Density]:
1.225g/cm3

[ Boiling Point ]:
661.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₄N₂O₅

[ Molecular Weight ]:
372.41500

[ Flash Point ]:
354.1ºC

[ Exact Mass ]:
372.16900

[ PSA ]:
85.89000

[ LogP ]:
3.22380

[ Index of Refraction ]:
1.595

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC7042000

CHEMICAL NAME :: Acetamide, N,N'-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-

CAS REGISTRY NUMBER :: 36141-82-9

BEILSTEIN REFERENCE NO. :: 2179741

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H24-N2-O5

MOLECULAR WEIGHT :: 372.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 3150 mg/kg

REFERENCE :: CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 22(4),59,1988

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%