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N-p-trans-Coumaroyltyramine

Names

[ CAS No. ]:
36417-86-4

[ Name ]:
N-p-trans-Coumaroyltyramine

[Synonym ]:
p-Coumaroyltyramine
2-Propenamide, 3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-, (2E)-
(2E)-3-(4-Hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide
(2E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide
N-trans-p-cumaroyltyramine
N-p-trans-Coumaroyltyramine
Paprazine

Biological Activity

[Description]:

N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 µM for T. brucei rhodesiense[1][2].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: 122 μM (AChE)[2]


[References]

[1]. Moradi-Afrapoli F, et al. Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity. Nat Prod Commun. 2012 Jun;7(6):753-5.

[2]. Kim DK, et al. Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase. Arch Pharm Res. 2003 Sep;26(9):735-8.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
586.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H17NO3

[ Molecular Weight ]:
283.322

[ Flash Point ]:
308.5±30.1 °C

[ Exact Mass ]:
283.120850

[ PSA ]:
69.56000

[ LogP ]:
2.24

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.655

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds