Oxantel

Names

[ Name ]:
Oxantel

[Synonym ]:
UNII-94AJJ30D9E
OXANTEL
Oxantelum

Biological Activity

[Description]:

Oxantel (CP-14445), a m-oxyphenol derivative of Pyrantel (HY-12641), is a N-subtype AChR agonist. Oxantel is an anthelmintic, with excellent trichuricidal properties[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

[Target]

nAChR[1][2]

[In Vitro]

Oxantel ( 0.015-600 µg/mL; 24-72 hours) reduces the viability of T. muris[1]. Cell Viability Assay Cell Line: T. muris Concentration: 0.015 µg/mL, 0.3 µg/mL, 0.6 µg/mL, 4.66 µg/mL, 9.375 µg/mL, 150 µg/mL, 600 µg/mL Incubation Time: 24 hours, 48 hours, 72 hours Result: Resulted in strongly reduced viabilities; resulted in strongly reduced viabilities within 24 hours but did not kill the worms.

[In Vivo]

Oxantel (1-10 mg/kg; i.p.) displays a high activity against T. muris in vivo, with an EC50 of 4.71 mg/kg[1]. Oxantel (10 mg/kg; i.p.) exhibits a worm burden reduction (WBR) of 92.5% and worm expulsion rate (WER) of 88.4% for T. muris[1]. Animal Model: 4 week-old female C57BL/10 mice and 3 week-old male[1] Dosage: 1 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg Administration: Intraperitoneal injection Result: Inhibited T. muris in vivo.

[References]

[1]. Richard J Martin, et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90.

[2]. V M Dale, et al. Oxantel-activated single channel currents in the muscle membrane of Ascaris suum. Parasitology. 1995 May;110 ( Pt 4):437-48.

Chemical & Physical Properties

[ Density]:
1.09g/cm3

[ Boiling Point ]:
383.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₆N₂O

[ Molecular Weight ]:
216.27900

[ Flash Point ]:
185.5ºC

[ Exact Mass ]:
216.12600

[ PSA ]:
35.83000

[ LogP ]:
1.51290

[ Index of Refraction ]:
1.575

Safety Information

[ HS Code ]:
2933599090

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%