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Sm4

Names

[ CAS No. ]:
365542-77-4

[ Name ]:
Sm4

[Synonym ]:
2-Hydroxy-6-[2-(2-naphthyl)ethyl]benzoic acid
Benzoic acid, 2-hydroxy-6-[2-(2-naphthalenyl)ethyl]-

Biological Activity

[Description]:

Sm4 is a SOX18 inhibitor. Sm4 shows SOX18-DNA binding inhibitory activity. Sm4 selectively affects SOX18 transcriptional output in vitro. Sm4 blocks SoxF transcriptional activity in vivo. Sm4 can be used for cancer metastasis and vascular cancers research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Mathias FRANCOIS. Inhibitors of sox18 protein activity for treating angiogenesis- and/or lymphangiogenesis-related diseases. Patent, WO2018112545A1.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
481.4±33.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H16O3

[ Molecular Weight ]:
292.32900

[ Flash Point ]:
259.1±21.9 °C

[ Exact Mass ]:
292.11000

[ PSA ]:
57.53000

[ LogP ]:
5.77

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.688

Related Compounds